In 2020 ORG LETT published article about BOND FUNCTIONALIZATION; DIAZO-COMPOUNDS; N-TOSYLHYDRAZONES; ORTHO-ARYLATION; ALKENYLATION; ACTIVATION; ALKYLATION; LIGANDS; DIAZOESTERS; OLEFINS in [Guo, Rui-Ting; Zhang, Ya-Lin; Tian, Jun-Jie; Zhu, Ke-Yu; Wang, Xiao-Chen] Nankai Univ, Tianjin, Peoples R China in 2020, Cited 56. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Application In Synthesis of 3-(Trifluoromethyl)phenol
ortho-Selective carbene C-H insertion of unprotected phenols is achieved with dimethyl diazomalonate under the catalysis of [Rh(COD)Cl](2). After the C-H insertion, subsequent cyclization and electrophilic addition of another carbene molecule affords tris-carboxylate-substituted 2-benzofuranones as the final reaction products. The enantioselective variant has been developed with the use of chiral diene ligands. Mechanistic experiments indicate that a transient oxonium ylide directing group might be responsible for the regiocontrol at the C-H activation step.
Application In Synthesis of 3-(Trifluoromethyl)phenol. Welcome to talk about 98-17-9, If you have any questions, you can contact Guo, RT; Zhang, YL; Tian, JJ; Zhu, KY; Wang, XC or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles