Recently I am researching about OCCUPATIONAL-EXPOSURE; IFOSFAMIDE; ASSAY, Saw an article supported by the Ministry of Economy and Competitiveness [MAT2012-38573-C02-01]; Departament d’Universitats, Recerca i Societat de la Informacio de la Generalitat de Catalunya [2017 SGR 1441]; Spanish National Plan for Scientific and Technical Research and Innovation 2013-2016; Instituto de Salud Carlos IIIInstituto de Salud Carlos IIIEuropean Commission; European Regional Development FundEuropean Commission; Spanish Ministry of Economy and Competitiveness [BES-2013-062819]; Iniciativa Ingenio 2010; Consolider Program. SDS of cas: 100-51-6. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Broto, M; McCabe, R; Galve, R; Marco, MP. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol
Personalized medicine is pushing forward new diagnostic techniques to aid in controlling drug therapeutic levels and their toxic effects. This study aims to develop a high-throughput screening method for therapeutic drug monitoring (TDM) and occupational exposure of cyclophosphamide (CP), an alkylating agent used as a chemotherapeutic and immunosuppressive drug. In order to achieve this goal, an immunizing hapten that exposes the cyclophosphamide moiety has been designed for the first time. Antibodies produced against this hapten have been used to develop an indirect competitive ELISA for the quantification of CP with high specificity and low cross-reactivity with some metabolites and other anticancer drugs. The assay obtained showed a LOD of 22 +/- 6 nM in serum samples, with concentrations much below the blood CP levels of patients treated with the drug. A new tool for the detection and quantification of CP is provided which could be relevant for future pharmacokinetic studies and for therapeutic index improvement.
SDS of cas: 100-51-6. Welcome to talk about 100-51-6, If you have any questions, you can contact Broto, M; McCabe, R; Galve, R; Marco, MP or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles