I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles published in 2020.0. Computed Properties of C7H6O2, Reprint Addresses Abdel-Mohsen, HT (corresponding author), Natl Res Ctr, Dept Chem Nat & Microbial Prod, Div Pharmaceut & Drug Ind Res, PO 12622, Cairo, Egypt.; El Kerdawy, AM (corresponding author), Cairo Univ, Fac Pharm, Dept Pharmaceut Chem, Kasr El Aini St,POB 11562, Cairo, Egypt.; El Kerdawy, AM (corresponding author), New Giza Univ, Fac Pharm, Dept Pharmaceut Chem, Km 22 Cairo Alexandria Desert Rd, Cairo, Egypt.; Senge, MO (corresponding author), Univ Dublin, St Jamess Hosp, Trinity Coll Dublin, Trinity Ctr Hlth Sci,Med Chem,Trinity Translat Me, Dublin 8, Ireland.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde
In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our design strategy is two-fold; it aimed first at studying the effect of replacing the 5-methylfuryl moiety of the well-known antiangiogenic 2-furylbenzimidazoles with an isopropyl moiety on the VEGFR-2 inhibitory activity and the cytotoxic activity. Our second objective was to further optimize the structures of the benzimidazole derivatives through elongation of the side chains at their one-position for the design of more potent type II-like VEGFR-2 inhibitors. The designed 1,2-disubstituted benzimidazoles demonstrated potent cytotoxic activity against the HepG2 cell line, reaching IC50 = 1.98 mu M in comparison to sorafenib (IC50 = 10.99 mu M). In addition, the synthesized compounds revealed promising VEGFR-2 inhibitory activity in the HepG2 cell line, e.g., compounds 17a and 6 showed 82% and 80% inhibition, respectively, in comparison to sorafenib (% inhibition = 92%). Studying the effect of 17a on the HepG2 cell cycle demonstrated that 17a arrested the cell cycle at the G2/M phase and induced a dose-dependent apoptotic effect. Molecular docking studies of the synthesized 1,2-disubstituted benzimidazoles in the VEGFR-2 active site displayed their ability to accomplish the essential hydrogen bonding and hydrophobic interactions for optimum inhibitory activity.
Computed Properties of C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Abdel-Mohsen, HT; Abdullaziz, MA; El Kerdawy, AM; Ragab, FAF; Flanagan, KJ; Mahmoud, AEE; Ali, MM; El Diwani, HI; Senge, MO or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles