Quality Control of 4′-Hydroxyacetophenone. In 2020.0 MOLECULES published article about POTENTIAL MULTIFUNCTIONAL AGENTS; ALZHEIMERS-DISEASE BRAIN; AMYLOID-BETA; BIOLOGICAL EVALUATION; BINDING-SITE; NEURODEGENERATIVE DISEASES; STRUCTURAL MODIFICATIONS; DESIGN; ACETYLCHOLINESTERASE; DERIVATIVES in [Chandrika, Nishad Thamban; Fosso, Marina Y.; Tsodikov, Oleg, V; Garneau-Tsodikova, Sylvie] Univ Kentucky, Coll Pharm, Dept Pharmaceut Sci, Lexington, KY 40536 USA; [LeVine, Harry, III] Univ Kentucky, Ctr Aging, Sch Med, Lexington, KY 40536 USA; [LeVine, Harry, III] Univ Kentucky, Sch Med, Dept Mol & Cellular Biochem, Lexington, KY 40536 USA in 2020.0, Cited 78.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.
The fact that the number of people with Alzheimer’s disease is increasing, combined with the limited availability of drugs for its treatment, emphasize the need for the development of novel effective therapeutics for treating this brain disorder. Herein, we focus on generating 12 chalcone-donepezil hybrids, with the goal of simultaneously targeting amyloid-beta (A beta) peptides as well as cholinesterases (i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)). We present the design, synthesis, and biochemical evaluation of these two series of novel 1,3-chalcone-donepezil (15a-15f) or 1,4-chalcone-donepezil (16a-16f) hybrids. We evaluate the relationship between their structures and their ability to inhibit AChE/BChE activity as well as their ability to bind A beta peptides. We show that several of these novel chalcone-donepezil hybrids can successfully inhibit AChE/BChE as well as the assembly of N-biotinylated A beta((1-42)) oligomers. We also demonstrate that the A beta binding site of these hybrids differs from that of Pittsburgh Compound B (PIB).
Welcome to talk about 99-93-4, If you have any questions, you can contact Chandrika, NT; Fosso, MY; Tsodikov, OV; LeVine, H; Garneau-Tsodikova, S or send Email.. Quality Control of 4′-Hydroxyacetophenone
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles