An article Lewis acid promoted double bond migration in O-allyl to Z-products by Ru-H complexes WOS:000466253900002 published article about NONREDOX METAL-IONS; CATALYZED ISOMERIZATION; OLEFIN ISOMERIZATION; DIOXYGEN ACTIVATION; Z-ALKENES; DEHYDROGENATION; MECHANISM; FACILE; CARBON in [Wang, Haibin; Liu, Shaodong; Sun, Tingting; Lv, Zhanao; Zhan, Zhen; Yin, Guochuan; Chen, Zhuqi] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Hubei Key Lab Mat Chem & Serv Failure, Key Lab Mat Chem Energy Convers & Storage,Minist, Wuhan 430074, Hubei, Peoples R China in 2019, Cited 49. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Name: m-Methoxyphenol
In catalytic double bond migration reaction, E-configuration olefins were normally generated as the dominant product because E-configuration was thermodynamically favored. However, Z-configuration products are sometimes desired in pharmaceutical chemistry owing to the structure-activity relationship. In this paper, we have demonstrated a new strategy that Lewis acid promoted an widely employed and convenient ruthenium(II) complex for the catalytic isomerization of O-allylethers, leading to thermodynamic-unfavored Z-product under mild conditions. The model substrate of allyl phenyl ether can be simply scaled up to 20 mmol to produce Z-product with TON of 2453 and TOF of 13,430 h(-1) at 40-60 degrees C. The system of Ru(II)/Lewis Acid catalysts was suitable for various substituted O-allylethers and other types of substrates. Through mechanism study including kinetic study, ligand inhibition effect and molecular spectroscopy, the dissociation of PPh3 ligand by the addition of Lewis acid, and the formation a five-membered Ru complex from anchimeric assistance were both recognized as essential steps to improve the reactivity and to control the stereoselectivity of catalytic double bond migration reaction through metal hydride addition-elimination mechanism. This new strategy may provide a new opportunity to produce thermodynamic-unfavored product in heterocyclic compounds for pharmaceutical chemistry.
Welcome to talk about 150-19-6, If you have any questions, you can contact Wang, HB; Liu, SD; Sun, TT; Lv, ZN; Zhan, Z; Yin, GC; Chen, ZQ or send Email.. Name: m-Methoxyphenol
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles