Formula: C8H6FNIn 2020 ,《Cobalt-Catalyzed Enantioselective Hydroarylation of 1,6-Enynes》 appeared in Journal of the American Chemical Society. The author of the article were Whyte, Andrew; Torelli, Alexa; Mirabi, Bijan; Prieto, Liher; Rodriguez, Jose F.; Lautens, Mark. The article conveys some information:
An asym. hydroarylative cyclization of enynes RCCCH2YCH2CH=CH2 [R = n-Bu, Ph, 2-thienyl, etc.; Y = O, NTs, C(COOEt)2, thiophene-2-sulfonamido] involving a C-H bond cleavage is reported. The cobalt-catalyzed cascade generates three new bonds in an atom-economical fashion. The products I (Ar = 2-acetylphenyl, N-acetyl-1H-indol-2-yl, 2-(pyridin-2-yl)phenyl, etc.) were obtained in excellent yields and excellent enantioselectivities as single diastereo- and regioisomers. Preliminary mechanistic studies indicate that the reaction shows no intermol. C-H crossover. This work highlights the potential of cobalt catalysis in C-H bond functionalization and enantioselective domino reactivity. The experimental part of the paper was very detailed, including the reaction process of 5-Fluoro-1H-indole(cas: 399-52-0Formula: C8H6FN)
5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Formula: C8H6FN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles