An efficient method for multicomponent synthesis of spiro[4H-pyran-oxindole] derivatives catalyzed by magnesium perchlorate was written by Wu, Chunlei;Shen, Runpu;Chen, Jianhui;Hu, Chunqi. And the article was included in Bulletin of the Korean Chemical Society in 2013.Synthetic Route of C8H4N2O4 This article mentions the following:
A simple and efficient method for the synthesis of spiro[4H-pyran-oxindole] derivatives by means of three-component reaction between isatins, malononitrile or Et cyanoacetate, and 1,3-dicarbonyl compounds in the presence of catalytic amount of magnesium perchlorate in 50% aqueous ethanol medium has been described. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Synthetic Route of C8H4N2O4).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Synthetic Route of C8H4N2O4
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles