From Indoles to Carbazoles: Tandem Cp*Rh(III)-Catalyzed C-H Activation/Bronsted Acid-Catalyzed Cyclization Reactions was written by Wu, Jia-Qiang;Yang, Zhen;Zhang, Shang-Shi;Jiang, Chun-Yong;Li, Qingjiang;Huang, Zhi-Shu;Wang, Honggen. And the article was included in ACS Catalysis in 2015.Synthetic Route of C8H6N2O2 This article mentions the following:
A tandem Cp*Rh(III)-catalyzed C-H activation/Bronsted acid-catalyzed intramol. cyclization allows a facile synthesis of carbazoles from readily available indoles. The reaction proceeds under rather mild reaction conditions with the generation of water and N2 as the only byproducts. Broad substrate scope, excellent functional group tolerance, and high yields were observed The benzannulation of pyrroles for the synthesis of indoles is also feasible using the same protocol. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Synthetic Route of C8H6N2O2).
6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Synthetic Route of C8H6N2O2
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles