On May 27, 2021, Wyand, Michael; Swiss, Gerald F. published a patent.Formula: C16H19NO6S The title of the patent was Low contaminant vaccines against microbes possessing a cell wall structure comprising poly-β-(1→6)-glucosamine (PNAG). And the patent contained the following:
Disclosed are antimicrobial vaccines (A-B)x-C, wherein A comprises 3 to 12 3-(1→6)-glucosamine I (carbohydrate ligand) groups; B is a linker; C is tetatus toxoid; x is an integer from about 30 to about 39; n is an integer from 1 to 10, wherein less than about 40% of the total number of such units are N-acetylated. The experimental process involved the reaction of Ethyl 2-deoxy-2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-1-thio-beta-D-glucopyranoside(cas: 130539-43-4).Formula: C16H19NO6S
The Article related to glucosamine pnag antimicrobial vaccine oligosaccharide preparation human fpa91, antimicrobial vaccine cell wall glucosamine oligosaccharide burn therapy, vaccine oligosaccharide glucsosamine tetanus toxoid carrier f598 monoclonal antibody and other aspects.Formula: C16H19NO6S
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles