Synthesis, Conformational Analysis, and Biological Evaluation of 1-Hexylindolactam-V10 as a Selective Activator for Novel Protein Kinase C Isozymes was written by Yanagita, Ryo C.;Nakagawa, Yu;Yamanaka, Nobuhiro;Kashiwagi, Kaori;Saito, Naoaki;Irie, Kazuhiro. And the article was included in Journal of Medicinal Chemistry in 2008.COA of Formula: C8H6N2O2 This article mentions the following:
Conventional and novel protein kinase C (PKC) isoenzymes are the main targets of tumor promoters. We developed 1-hexylindolactam-V10 (I) as a selective activator for novel PKC isoenzymes that play important roles in various cellular processes related to tumor promotion, ischemia-reperfusion injury in the heart, and Alzheimer’s disease. The compound existed as a mixture of three conformers. The trans-amide restricted analogs of I hardly bound to PKC isoenzymes, suggesting that the active conformation of I could be that with a cis-amide. Compound I selectively translocated novel PKC isoenzymes over conventional PKC isoenzymes in HeLa cells at 0.1-1 渭M. These results suggest that I could be useful for the functional anal. of novel PKC isoenzymes. In the experiment, the researchers used many compounds, for example, 4-Nitroindole (cas: 4769-97-5COA of Formula: C8H6N2O2).
4-Nitroindole (cas: 4769-97-5) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.COA of Formula: C8H6N2O2
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Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles