An article Concise, scalable and enantioselective total synthesis of prostaglandins WOS:000655716500001 published article about GENERAL STRATEGY; ACCESS in [Zhang, Fuhao; Zeng, Jingwen; Gao, Mohan; Wang, Linzhou; Chen, Gen-Qiang; Zhang, Xumu] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Shenzhen, Peoples R China; [Zhang, Fuhao; Zeng, Jingwen; Gao, Mohan; Wang, Linzhou; Chen, Gen-Qiang; Zhang, Xumu] Southern Univ Sci & Technol, Dept Chem, Shenzhen, Peoples R China; [Zhang, Fuhao; Lu, Yixin] Natl Univ Singapore, Dept Chem, Singapore, Singapore; [Chen, Gen-Qiang; Zhang, Xumu] Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Medi X, Shenzhen, Peoples R China in 2021, Cited 31. The Name is 3-(Trifluoromethyl)phenol. Through research, I have a further understanding and discovery of 98-17-9. Application In Synthesis of 3-(Trifluoromethyl)phenol
Prostaglandins are among the most important natural isolates owing to their broad range of bioactivities and unique structures. However, current methods for the synthesis of prostaglandins suffer from low yields and lengthy steps. Here, we report a practicability-oriented synthetic strategy for the enantioselective and divergent synthesis of prostaglandins. In this approach, the multiply substituted five-membered rings in prostaglandins were constructed via the key enyne cycloisomerization with excellent selectivity (>20:1 d.r., 98% e.e.). The crucial chiral centre on the scaffold of the prostaglandins was installed using the asymmetric hydrogenation method (up to 98% yield and 98% e.e.). From our versatile common intermediates, a series of prostaglandins and related drugs could be produced in two steps, and fluprostenol could be prepared on a 20-gram scale.
Application In Synthesis of 3-(Trifluoromethyl)phenol. About 3-(Trifluoromethyl)phenol, If you have any questions, you can contact Zhang, FH; Zeng, JW; Gao, MH; Wang, LZ; Chen, GQ; Lu, YX; Zhang, XM or concate me.
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