Development of a Metal- and Oxidant-Free Enzyme-Photocatalyst Hybrid System for Highly Efficient C-3 Acylation Reactions of Indoles with Aldehydes was written by Yu, Yuan;Lin, Ru-De;Yao, Yao;Shi, Ming-Liang;Lu, Wei-Fan;Wang, Na;Yu, Xiao-Qi. And the article was included in ACS Catalysis in 2022.Formula: C11H11NO This article mentions the following:
An enzyme-photocatalyst hybrid system has been developed for aldehyde-based indole C-3 acylation. The concept of this process is to form a C-N bond through the three-component Mannich reaction of aldehydes RCHO (R = H, Ph, pyridin-2-yl, thiophen-2-yl, etc.), amines, such as 4-fluoroaniline, 2-aminopyrimidine and indoles I (R1 = H, 4-Me, 5-F, 6-Cl, etc.; R2 = Me, Ethyl; R3 = H, Me), thereby introducing an aminomethyl group on the indole ring. Next, this system catalyzed the formation of the corresponding imide ion from the Mannich product, followed by rapid hydrolysis to give the final C-3 carbonyl indole product II. More than 30 indole C-3 acylated products II (up to 93% yield) were successfully synthesized under mild conditions, and indole derivatization of two bioactive substances (probenecid and cholesterol) was realized. The mechanistic study provides theor. support for the construction of photoenzyme catalytic systems. This is an example of enzyme-light-activated C-3 acylation of indoles I under very mild reaction conditions, without the use of transition metal catalysts, metal salts, and addnl. oxidants. This efficient enzyme-photocatalyst hybrid system provides a strategy for the development of photoenzyme catalysis fields. In the experiment, the researchers used many compounds, for example, 1,4-Dimethyl-1H-indole-3-carbaldehyde (cas: 170489-16-4Formula: C11H11NO).
1,4-Dimethyl-1H-indole-3-carbaldehyde (cas: 170489-16-4) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Formula: C11H11NO
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles