Synthesis and reactivity of new amide-substituted oxindole derivatives was written by Zaryanova, Ekaterina V.;Ignatov, Alexander A.;Lozynskaya, Nataly A.. And the article was included in Tetrahedron in 2017.Application In Synthesis of 7-Nitroindoline-2,3-dione This article mentions the following:
A general approach to the synthesis of oxindole-based amides I (R = 5-NHC(O)OMe, 5-NHCOPh, 5-NHCOPh-7-NHCOMe, etc.) is described. To stabilize the aminoisatin mol. for further modifications, the carbonyl group in the 3-position of the starting nitroisatins was protected by conversion into a ketal. Next, the reduction of the nitro group and further acylation of the resulting amino group were carried out to provide the corresponding mono- and diamido-substituted isatins I. The possibility of their modification in the 3-position for the synthesis of potent biol. active compounds is demonstrated. In the experiment, the researchers used many compounds, for example, 7-Nitroindoline-2,3-dione (cas: 112656-95-8Application In Synthesis of 7-Nitroindoline-2,3-dione).
7-Nitroindoline-2,3-dione (cas: 112656-95-8) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Application In Synthesis of 7-Nitroindoline-2,3-dione
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles