Palladium-Catalyzed Three-Component Regioselective Dehydrogenative Coupling of Indoles, 2-Methylbut-2-ene, and Carboxylic Acids was written by Zhang, Xing-Long;Guo, Rui-Li;Wang, Meng-Yue;Zhao, Bao-Yin;Jia, Qiong;Yang, Jin-Hui;Wang, Yong-Qiang. And the article was included in Organic Letters in 2021.Product Details of 4769-96-4 This article mentions the following:
An unprecedented palladium-catalyzed three-component dehydrogenative cascade coupling of indoles, 2-methylbut-2-ene, and carboxylic acids or methanol has been developed. The approach enables the straightforward introduction of a C3′-bonded five-carbon structural unit with a tertiary alc. quaternary carbon center giving access to functionalized indoles I (R1 = H, 5-Me, 6-Br, 6-NO2, etc.; R2 = Me, n-pentyl, Ph, 2-thienyl, etc.; R3 = Me, MeCO, cyclopropylcarbonyl, ClCHMeCO, etc.). The protocol employs 2-methylbut-2-ene as the C5 source and features a broad substrate scope, atom and step economies, and high chemo- and regioselectivies. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Product Details of 4769-96-4).
6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Product Details of 4769-96-4
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Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles