Efficient preparation of polyfunctional indoles via a zinc organometallic variation of the Fischer indole synthesis was written by Zhang, Zhi-Guang;Haag, Benjamin A.;Li, Jin-Shan;Knochel, Paul. And the article was included in Synthesis in 2011.Synthetic Route of C10H10BrN This article mentions the following:
Functionalized organozinc reagents readily react with various aryldiazonium salts furnishing regioselectively polyfunctional indoles after heating with microwave irradiation This new organometallic variation of the Fischer indole synthesis tolerates a wide range of functional groups and can be readily scaled up. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Synthetic Route of C10H10BrN).
5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Synthetic Route of C10H10BrN
Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles